尿路感染患者病原菌分布及耐药趋势分析

Distribution and Antibiotic Resistance of Pathogenic Bacteria in Patients with Urinary Tract Infections

目的:分析我院尿路感染常见的病原菌分布及其对抗菌药物耐药情况,为临床合理使用抗菌药物提供科学依据。方法:收集我院2006年625份尿路感染尿液标本及其对分离出344株细菌进行培养及药敏试验。结果:G-杆菌最多(60·2%),G+球菌其次(33·4%),真菌最少(6·4%)。产超广谱β-内酰胺酶大肠埃希菌和肺炎克雷伯菌的检出率分别为49·2%和27·3%。细菌对各种抗菌药物有不同程度的耐药率,表现为多重耐药。结论:尿路感染应及时进行尿液细菌培养及药敏试验,慎重应用抗菌药物,以减少耐药菌的产生。

OBJECTIVE： To analysis the distribution and antibiotic resistance of common isolated pathogenic bacteria in urinary- tract infection cases in our hospital so as to provide scientific basis for the rational clinical use of antibacterials.METHODS： 625 urine samples were collected from urinary - tract infection cases in our hospital in 2006, from which, 344 strains of bacteria were isolated, which were cultured and subjected to drug sensitivity test .RESULTS： Of the 344 strains of bacteria, Gram negative bacilli took the lead, accounting for 60.2% of the total, followed by Gram-positive cocci（33.4%） and fungi （6.4%） .The detection rates of ESBLs - producing Escherichia coli. and Klebsiella pneumoniae were 49.2% and 27.3%, respectively.The bacteria had different resistant rate to different antibiotics and were multidrug resistant.CONCLUSION： Bacterial culture of urine and drug- sensitivity test should be performed promptly and drugs should be used with prudence for urinary infection cases to reduce drug - resistance bacteria.