BNAH还原质子化N-芳基芴亚胺反应的热力学及机理研究

Mechanism and Energetics of the Reductions of Protonated N-Arylfluroenimine by BNAH

利用热力学循环方法，通过pKa和有关电化学数据的测定，首次得到NAD（P）H辅酶模型物（BNAH）按不同机理还原质子化N-芳基芴亚胺的各基元步骤的自由能变化．结合得到的同位素标记结果，从热力学起动力的角度区分了氢负离子的转移机理.

Free energy changes of each primary steps in one-step hydride transfer and multistep transfer mechanisms in the reductions of protonated N-arylfluorenimines by an NAD (P) H model, BANH, were derived from approprlate thermodynamic cycles by combining PK. and relevant electrochemical data, The mechanism of the reduction was proposed as onestep hydride transfer from thermodynamic points of view and the isotope-labelling experiments.