一类新型酰基脲化合物的设计、合成及生物活性

Studies on the Design,Synthesis and Biological Activity of a Novel Type of Acylurea Compound

设计并合成了21个新型含呋喃环的双酰基脲化合物，经IR、1HNMR、MS和元素分析确证其结构．初步生物活性测定结果表明，该类化合物具有几丁质抑制活性．

In order to find new insectlcldes possessing a high activity and excellent selectivity, a novel type of diacylurea containing furan has been designed and prepared. Thus, by the nucleophilic addition reaction of 5-substituted futamide and benzoyl isocyanate, 21 compounds of N-benzoyl-N'-[5-substituted furoyl]urea were obtained in 74. 5 % ～ 99. 5 % yield.Their structures were confirmed by elementary analysis, IR, 1H NMR and MS. The result of preliminary bioassay demonstrates that some of them show chitin-inhibiting activity against mosqito larvae at 10 mg/L. Especially, compounds 1, 15 and 21 exhibited ＞8O%mortality to larval mosquitoes with the same dead symptom as IKI-7899.