芳基不同型双并四氢呋喃木脂素的新合成方法

A New Synthetic Route to Furofuran Lignans with Two Different Aryl Groups─Synthesis of (±)-Methyl Piperitol

双井四氢峡哺木脂素是木脂素中结构较为复杂的一类化合物[1]．由于该类化合物在抑制磷酸二酯酶活性、抗高血压、抗氧化等方面具有显著的生理活性[2]，因此引起了药物学家和合成化学家的广泛关注[3]．但有关具有2个不同芳基的双并四氢呋喃木脂素的合成方法研究却很有限，所...

(±)-Methyl plperitol, a representative example of furofuran lignans with two different aryl groups was synthesized starting from vanillin and piperonal by employlng a connecting of bromo-β-keto ester and sodium salt of another β-keto ester as the key step.