摘要
本文研究了弱碱化合物保留值方程(lnk=a+cCb-ln(1+1014Kb[H+])),根据色谱动力学和色谱热力学原理编辑了相应软件,应用该软件优化出奥美拉唑及其代谢物和内标物的高效液相色谱分离条件。
The retention formula for alkaloid,ln k =a+cCb-ln(1+10 14 Kb),was studied by the authors, and a corresponding soft ware was edited based on principles of chromatographic thermodynamics and dynamics. The optimized conditions for HPLC separation of omeprazole and its metabolites and internal standards were worked out by using this sofe ware. Then the studies on pharmacokinetics of omeprazole in health volunteers were achieved
出处
《分析测试学报》
CAS
CSCD
1997年第2期48-53,共6页
Journal of Instrumental Analysis
关键词
色谱优化法
奥美拉唑
药物代谢动力学
体内
Chromatogaphic optimum, Computer imitation, Omeprazole, HPLC, Pharmacokinetics.