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对酞内酰胺苯甲酰氯柱前衍生反应HPLC法检测痕量芳香胺 被引量:6

HPLC Determination of Trace Aromatic Amines by Pre column Derivatization with 4 (2 Phthalimidyl)Benzoyl Chloride
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摘要 建立了一种快速、灵敏检测痕量芳香胺的新方法。对苯胺、邻甲苯胺和间甲苯胺与对酞内酰胺苯甲酰氯(简称PIB-Cl)的衍生反应条件、衍生物色谱分离及定量检测条件等进行了研究。衍生试剂在有机溶剂中与3种芳香胺反应迅速,衍生物用乙腈+水(48+52)作流动相,在反相色谱系统中得到了良好的分离。3种芳香胺的检出限分别为:苯胺1.5pmol,邻甲苯胺和间甲苯胺均为2.0pmol。 The paper covers a simple,rapid and sensitive method for determination of trace aniline and toluidines by HPLC. The optimum experimental conditions have been established. Firstly, the samples were treated with 4 (2 phthalimidyl)benzoyl chloride, then produce the corresponding amides which can be separated on ODS column with acetonitrile/water (48/52,V/V)as mobile phase. The eluates were quantitatively detected by UV detector at 295 nm. The detection limits were 1.5 pmol for aniline and 2.0 pmol for both o and m toluidine.
出处 《分析测试学报》 CAS CSCD 1997年第2期61-63,共3页 Journal of Instrumental Analysis
关键词 芳香胺 高效液相色谱 柱前衍生 HPLC 芳胺 Aromatic amines, 4 (2 Phthalimidyl) benzoyl chloride, HPLC.
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