腺苷脱氨酶活性与肝脏疾病的关系

The clinical value of adenosine deaminase for diagnose of liver disease

目的:探讨腺苷脱氨酶在肝脏疾病中的诊断价值。方法:应用全自动生化分析仪检测肝病患者血清腺苷脱氨酶(ADA)及肝功能各项指标。结果:脂肪肝患者血清ADA无明显升高;慢性乙型肝炎、急性肝炎、肝硬化及肝硬化合并肝癌患者血清ADA活性明显增高,与正常组比较有统计学意义(P<0.01);肝硬化患者、肝硬化合并肝癌患者血清ADA活性较慢性乙型肝炎患者明显升高,两组比较有统计学意义P<0.01);急性肝炎患者经治疗血清ADA明显降低,与发病早期比较有统计学意义(P<0.05);肝病患者血清ADA与白球蛋白比值、前白蛋白呈负相关,与总胆红素呈正相关。结论:肝病患者血清ADA增高提示肝病慢性化、逐渐进展,反映肝脏损害程度加重,肝脏储备、合成功能逐渐降低。

To investigate the relationship of adenosine deaminase and diagnose of liver disease. Methods： The adenosine deaminase and liver function tests of patient were detected by ACCUTE TBA-40FR. Results： In this study, the serum adenosine deaminase of chronic hepatitis, acute hepatitis, hepatic cirrhosis and primary hepatic carcinoma were remarkahlely higher than the control group （P 〈 0. 01 ）, hut not elevated in fatty liver patient, the serum adenosine deaminase of hepatic cirrhosis and primary hepatic carcinoma were remarkablely higher than the chronic hepatitis patient （P 〈0. 01 ） . The serum adenosine deaminase of acute hepatitis after treatment was markedly decrease than onset （ P 〈 0. 05 ） . The serum adenosine deaminase was correlated negatively with serum albumin and A/G. The serum denosine adeaminase was correlated positively with total hilirubin. Conclusion： The higher serum adenosine deaminase expresses the worse liver illness and the chronic hepatitis. It could reflect the decrease of liver synthesization function and aggravation of liver disease,