胃癌化疗前后循环血浆VEGF、IL-8变化的临床意义

Expressions of plasma VEGF,IL-8 before and after chemotherapy in gastric cancer patients

目的探讨VEGF、IL-8在胃癌患者化疗前后血浆中表达的临床意义。方法采用酶联免疫吸附法(ELISA)分别检测45例胃癌患者化疗前后血浆VEGF、IL-8水平,10名正常健康志愿者血浆作为对照。结果恶性肿瘤组化疗前血浆VEGF、IL-8含量明显高于对照组(P<0.001),与TNM分期有关,但与肿瘤组织分化类型无明显相关性。化疗后血浆VEGF、IL-8显著下降(P<0.001)。结论VEGF、IL-8是肿瘤发展和转移的有效生物学指标。化疗后VEGF、IL-8的表达量可能有助于临床判断化疗近期疗效。

Objective To investigate the clinical significance of expressions of plasma VEGF, IL-8 before and after chemotherapy in gastric cancer patients. Methods The plasma VEGF, IL-8 were measured in 45 gastric cancer patients before and after chemotherapy. Meanwhile, 10 healthy volunteers were involved in the control. Results VEGF, IL-8 plasma levels before chemotherapy were found significantly higher in cancer patients than that in the controls （P 〈 0. 001 ）. Moreover, they were significantly increased in stage N patients compared with that in the stage Ⅱ and stage Ⅲ patients. But there was no relationship with differentiation. VEGF, IL-8 plasma levels were decreased significantly after chemotherapy （P 〈 O. 001 ）. Conclusion VEGF, IL-8 are useful biological marks in finding out recurrence and metastasis. The levels of VEGF, IL-8 after chemotherapy may reflect the therapeutic effect.