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可诱导性共刺激分子的生物学特征及其在系统性红斑狼疮发病和治疗中的作用 被引量：1

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摘要 系统性红斑狼疮（systemic lupus erythematosus，SLE）是一种由于机体免疫调节紊乱所致的慢性炎性疾病。T、B细胞的异常活化以及炎性因子异常导致了SLE患者的多器官、系统损害。已证实，T细胞活化、B细胞增殖、分化和细胞因子分泌中，CD28、细胞毒性T淋巴细胞相关抗原4（CTLA-4）等共刺激分子及其配体发挥了重要作用，
作者 潘海峰 叶冬青
机构地区 安徽医科大学公共卫生学院流行病与卫生统计学系
出处 《中华风湿病学杂志》 CAS CSCD 2008年第3期198-200,共3页 Chinese Journal of Rheumatology
基金 基金项目：国家自然科学基金资助项目（30571608） 安徽省自然科学基金资助项目（070413109）
关键词 系统性红斑狼疮 共刺激分子 生物学特征 ERYTHEMATOSUS 细胞毒性T淋巴细胞相关抗原 可诱导性 T细胞活化 B细胞增殖
分类号 R686 [医药卫生—骨科学]
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参考文献27

  • 1Hutloff A, Dittrich AM, Beier KC, et al. ICOS is an inducible T- cell co-stimulator structurally and functionally related to CD28. Nature, 1999, 397: 263-266.
  • 2Okamoto T, Saito S, Yamanaka H, et al. Expression and function of the co-simulator H4/ICOS on activated T cells of patients with rheumatoid arthritis. J Rhcumatol, 2003, 30:1157-1163.
  • 3Wiendl H, Neuhaus O, Mehling M, et al. The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis. J Neuroimmunol, 2003, 140: 177-187.
  • 4Flesch IE. Inducible costimulator (ICOS). J Biol Regul Homeost Agents, 2002, 16:214-216.
  • 5Swallow MM, Wallin JJ, Sha WC, et al. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity, 1999, 11: 423-432.
  • 6Khayyamian S, Hutloff A, Büchner K, et al. ICOS-ligand, expressed on human endothelial cells, costimulates Thl and Th2 cytokine secretion by memory CD4^+ T cells. Proc Natl Acad Sci USA, 2002, 99: 6198-6203.
  • 7Carreno BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol, 2002, 20: 29-53.
  • 8Mages HW, Hutloff A, Heuck C, et al. Molecular cloning and characterization of murine ICOS and identification of BTh as I- COS ligand. Eur J Immunol, 2000, 30: 1040-1047.
  • 9Beier KC, Hutloff A, Dittrich AM, et al. Induction, binding specificity and function of human ICOS. Eur J Immunol, 2000, 30: 3707-3717.
  • 10Dong C, Juedes AE, Temann UA, et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature, 2001. 409: 97-101.

二级参考文献29

  • 1Criscione LG, Pisetsky DS. B lymphocytes and systemic lupus erythematosus. Curr Rheumatol Rep, 2003, 5: 264-269.
  • 2Seo SJ, Fields ML, Buckler JL, et al. The impact of T helper and Tregulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity, 2002, 16: 535-546.
  • 3Hutloff A, Dittrich AM, Beier KC, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature,1999, 397: 263-266.
  • 4lwai H, Abe M, Hirose S, et al. Involvement of inducible costimulatot-B7 homologous protein costimulatory pathway in routine lupus nephritis. J Immunol, 2003, 171: 2848-2854.
  • 5Bombardier C, Gladman DD, Urowitz MB, et al. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum, 1992, 35: 630-640.
  • 6Mages HW, Hutloff A, Heuck C, et al. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur J Immunol, 2000, 2,0: 10d0-10d7.
  • 7Khayyamian S, Hutloff A, Büchner K, et al. ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory T cell. Proc Natl Acad Sci U S A,2002,99: 6198-6203.
  • 8Nurieva RI, Mai XM, Forbush K, et al. B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci U S A,2003,100:14163-14168.
  • 9Nanji SA, Hancock WW, Anderson CC,et al. Combination therapy with anti-ICOS and cyclosporine enhances cardiac but not islet allograft survival. Transplant Proc, 2003, 35:2477-2478.
  • 10Rottman J B, Smith T, Tonra J R, et al. The costmulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nature, 2001,2: 605-611.

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中华风湿病学杂志
2008年 第3期

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