摘要
目的:考查多索茶碱、尼克刹米、洛贝林、甲泼尼龙琥珀酸钠注射剂的配伍稳定性。方法:观察及测定4种注射剂在5%葡萄糖氯化钠注射液和0.9%氯化钠注射液中配伍后室温放置8 h内的外观、不溶性微粒及pH。采用HPLC法测定配伍液室温放置8 h内的含量变化。结果:与配伍0h比较,配伍液放置8 h内的外观色泽、不溶性微粒及含量均无明显变化,pH略有变化。配伍液中各药含量在8 h内保持在90%以上,且配伍8 h内无新物质产生。结论:多索茶碱、尼克刹米、洛贝林、甲泼尼龙琥珀酸钠注射剂在5%葡萄糖氯化钠注射液和0.9%氯化钠注射液中配伍后于室温放置8 h内质量基本稳定。
Objective ： To study the compatible stability of Doxofylline for Injection, Nikethamide injection, Lobeline Hydrochoride injection and methylprednisolone sodium succinate for Injection. Method： The changes in appearance, particles and pH of the mixture of the four injections in 5% glucose and sodium chloride injection and 0.9% sodium chloride injection within 8 hours at ambient temperature were observed, the concentrations of the mixture of the four injections in 5% glucose and sodium chloride injection and＇0.9% sodium chloride injection were determined by HPLC within 8 hours. Result： Compared with the solutions at Oh of mixing, no signifi- cant changes were noted in color, clarity, particles and concentration within 8 hours mixing. However, there were a few changes in their pH values. Conclusion： The mixture of doxofylline for Injection, nikethamide injection, lobeline hydrochoride injection and methylprednisolone sodium succinate for injection in 5% glucose and sodium chloride injection and 0.9% sodium chloride injection is stable in quality within 8 hours mixing at ambient temperature.
出处
《中国药师》
CAS
2008年第3期310-313,共4页
China Pharmacist
