乙醇使MDMA所致5-羟色胺神经元损伤加重

Increase in MDMA-induced serotonin neuronal damage caused by ethanol

3.4-亚甲二氧基苯丙胺(MDMA,迷魂药)为合成的苯丙胺衍生物,作为娱乐消遣物质为青年人广泛滥用。MDMA主要作用于5-羟色胺能系统,并能引起5-羟色胺神经元损伤。其神经毒性作用机制可能和羟基自由基的形成有关。MDMA常和乙醇合并滥用。乙醇可促使羟基自由基增多,并使5-羟色胺神经元损伤加重。

3,4-methylenedioxyme thamphetamine （MDMA, ecstasy） is a synthetic amphetamine derivative, which is used as a recreational substance and is widely abused among young people. MDMA targets the serotonergic system and can cause serotonin neuronal damage. The mechanism responsible for the neurotoxicitg of MDMA is probably associated with hydroxyl radical formation. MDMA abuse commonly occurs in combination with ethanol, and ethanol can increase hydroxyl radicals formation and serotonin neuronal damage.