摘要
1名56岁男性患者,因风湿性关节炎口服塞来昔布200mg。约2h后双上肢出现散在的多形性红斑,随即红斑遍布全身,伴灼热、瘙痒、渗出,患者表现为发热(T38℃)、胸痛、排尿困难,眼睑和上唇水肿,口腔黏膜和尿道口充血。实验室检查:WBC10.5×109/L,N0.709,L0.201。给予抗过敏和对症治疗3d后,症状缓解,1周后红斑完全消退,但皮肤留下明显色素沉着。
A 56-year-old man took celecoxib 200mg for rheumatic arthritis. About 2 hours later, he developed sporadic erythema muhiforme on the upper limbs, and then it progressed to involve his entire body, accompanied with calor, pruritus, and effusion. The patient presented with a fever （T 38℃ ）, chest pain, dysuresia, edema of the eyelids and upper lip, and hyperaemia of oral mucosa and urethral orifice. Laboratory test showed a WBC count of 10.5 × 10^9/L with 70.9% neutrophils and 20.1% lymphocyte. The symptoms were relieved three days after anti-anaphylactic and symptomatic treatment. One week later, erythema almost completely faded, but marked pigmentation remained in the skin lesions.
出处
《药物不良反应杂志》
2008年第1期63-63,共1页
Adverse Drug Reactions Journal
