少腹逐瘀颗粒引起肝损害

Liver damage induced by Shaofuzhuyu granules

患者女,27岁,因人工流产后月经不调口服少腹逐瘀颗粒1.6g,3次/d。服药2个月后,患者出现皮肤及尿色发黄。又继续的服药1月余,症状加重伴乏力、恶心、呕吐,检查显示肝功能异常,即停用少腹逐瘀颗粒,并经保肝治疗2周未缓解而入院。查ALT130U/L,AST330U/L,TBil141.4μmol/L,DBil130.7μmol/L,甲、乙、丙、丁、戊型肝炎病毒学检测均阴性,肝活组织免疫病理未检测到肝炎病毒,诊断为药物性肝损害。给予谷胱甘肽、复方甘草酸苷、多烯磷脂酰胆碱等治疗。3周后,患者症状消失,肝功能恢复正常而出院。

A 27-year-old female patient received oral Shaofuzhuyu granules 1.6 g thrice daily for menoxenia after artificial abortion. Two months after administration, the patient developed yellowish of the skin and dark urine. She continued to take Shaofuzhuyu granules for more than 1 month, and her symptoms were worsen accompanied by asthenia, nausea, and vomiting. Examination showed her liver function was abnormal. Shaofu, zhuyu granules were discontinued. Despite liver-protective treatment for two weeks, her symptoms were not relieved. The patient was then admitted to hospital. Liver function tests revealed the following levels： ALT 130 U/L, AST 330 U/L, TBil 141.4 μmol/L, and DBil 130.7μmol/L. A virological examinatition showed that hepatic A, B, C, D, and E viruses were negative, and a immunopathologic examinatin of liver tissue revealed there was no hepatitis virus. She was diagnosed with drug-induced liver damage and was treated with glutathione, compound glycyrrhizin, polyene phosphatidylcholine. Three weeks later, the patien symptoms disappeared, her liver function returned to normal limits and she was discharged.