消化道肿瘤时辰调节化疗的临床观察及护理

Clinical Observation and nusing care of the chrono-adjusted chemotherapy in Digestive Tract Tumor

目的:探讨化疗时辰调节给药方法治疗消化道肿瘤的毒性反应及护理对策。方法:经组织病理学证实需化疗的消化道肿瘤患者100例,随机分为时辰组和对照组各50例,两组用药剂量、治疗周期均相同,时辰组根据抗肿瘤药物血药浓度高峰制定用药时间,对照组采用常规时间化疗,观察两组化疗后出现不良反应类型及程度。结果:时辰组各种类型毒副反应的程度较对照组轻(P<0.05)。结论:时辰化疗方法具有操作简单、反应轻、毒性低等优点,可在临床上推广使用;正确及时的护理对患者耐受时辰化疗有肯定作用,但对护理工作提出更高要求。

Objective To investigate the toxic reaction and effect of nursing care for patients with digestive tract tumor treated with the chrono-adjusted chemotherapy. Method 100 patients with digestive tract tumor confirmed by histopathology undergoing chemotherapy were randomly dirided into a study group and control group （n=50 each）. Both group patients received the same dose intensity and treatment cycles. Patients of study group were administrated medication based on the peak of blood drug levels of anti - tumor drugs. While patients of control group under- went routine chemotherapy. Then categories and extents of adverse reactions of the two groups patients after chemotherapy were observed. Results The extent of each category of toxic reactions and side effects of study group patients were less than that of control group （P〈0.05）. Conclusion The chrono-adjusted chemotherapy has simpleoperated and the lower side effects and reactions. The high quality nusing work was required for the novel treatment, which might be recommended to put into clinical practise.