尿微量蛋白检测对早期糖尿病肾病诊断的意义

Clinical significance of micro-amount of urinary proteins detection for patients with early diabetic nephropathy

目的探讨尿微量蛋白测定在糖尿病肾病（DN）早期诊断的意义。方法用RIA法分别测定95例早期DN患者（以尿白蛋白排泄率持续20-200μg／min为标准诊断，患者组A），80例无DN的糖尿病患者（患者组B）和82例正常健康人（对照组晨尿中的微量白蛋白（Micro—albumin，mAlb）、β2-微球蛋白（β2-microglobulin，β2-m）和α1-微球蛋白（α1-microglobulin，α1-m）的水平。结果患者组A与患者组B及对照组比较，各项检测指标均增高，而患者组B与对照组均相近。结论DN早期肾损害与尿微量蛋白密切相关，尿mAlb、β2-m和α1-m是反映早期DN的敏感指标。

Objective To investigate the diagnostic significance of mlcro-amount of urinary proteins detection in patients with early diabetic nephropathy. Methods Urinary mlcro-amount of albumin （MA） and β2-mieroglobulin（β2- m） ,α1-microglobulin, （α1-m）contents were measured by radioimmunoassay in： （1） Group A,95 type 2 diabetes mellitus （DM-2） patients with early DN （urinary albumin excretion rate ： 20-200 μg/min） （2） Group B 80 DM -2 patients without DN and （3） 82 controls. Results Urinary contents of all these three kinds of proteins in Group A were significantly higher than those in Group B and controls（P〈0. 05）. However, the contents in Group B were similar with controls. Conclusion Urinary MA, β2-m and α1-m are sensitive markers for detecting early DN.