62例肾病综合征临床病理分析

Clinical and pathological analysis on 62 cases of nephrotic syndrome

目的探讨肾病综合征患者临床表现与肾脏病理的关系。方法对符合尿蛋白>3.5g/24h及血清白蛋白<30g/L诊断标准的62例肾病综合征患者进行经皮肾活检术,通过光镜、免疫病理及电镜检查明确病理分型。结果62例肾病综合征患者中常见的病理类型为系膜增生性肾小球肾炎(25.81%)、微小病变(17.74%)、IgA肾病(11.29%)、膜性肾病(8.07%)和狼疮性肾炎(27.42%),通过肾活检纠正5例临床诊断。结论肾活检病理对肾病综合症征诊断、治疗及预后评估有重要意义。

Objective To research the relationship between clinical manifestations and pathological findings in patients with nephrotic syndrome. Methods Renal biopsy was conducted for 62 nephrotic syndrome disease patients, which were coincident to the diagnostic standard that the urinary protein was 〉3. 5g/24 hours and plasma albumin 〈30 g/L. Pathologic diagnosis was ascertained by light microscopy, immunohistofluorescent microscopy and electron microscopy. Results In the 62 patients, the most frequent pathologic type was mesangial proliferative glomerulonephritis （25. 81%）, minimal change glomerulopathy （12. 90%）, IgA nephropathy （11. 29% ）, membranous glomerulopathy（8.07% ）, and lupus nephritis（27.42% ）. The clinic diagnosis of 5 patients was rectified by renal biopsy. Conclusion Renal biopsy plays an important role in the diagnosis, treatment and prognosis evaluation in patients with nephritic syndrome.