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氯吡格雷联合氟伐他汀治疗脑梗塞的临床观察 被引量:22

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摘要 目的观察氯吡格雷联合氟伐他汀治疗脑梗塞的疗效。方法将符合入选标准的320例患者随机分为治疗组和对照组各160例,治疗组在常规治疗的基础上加用氯吡格雷和氟伐他汀。分别于治疗后7天,15天,30天和60天对患者进行欧洲脑卒中评分(ESS),日常生活活动能力评分(ADL)和疗效评定。治疗前和治疗后1个月抽血查高敏C反应蛋白(hs-CRP);基质金属蛋白酶9(MMP-9)。治疗前及治疗后2个月抽血行血脂检测。结果治疗组1个月后hs-CRP及MMP-9与治疗前及对照组比较差异均有显著性;治疗3月后治疗组与对照血脂比较差异有显著性;治疗后7天,15天,30天和60天治疗组与对照组比较ESS及ADL评分差异均有显著性。结论氯吡格雷联合氟伐他汀治疗脑梗塞能有效改善脑梗塞患者日常生活活动能力和神经功能缺损。是一种较好的治疗脑梗塞的方法。
出处 《西部医学》 2008年第2期322-324,共3页 Medical Journal of West China
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