乙型肝炎病毒转录调控的研究进展

Advanced on research of HBV transcriptional regulation

乙型肝炎病毒(Hepatitis B virus,HBV)基因组由一个约3.2 kb的环形DNA组成,包含了C、P、S和X 4个基因开放读码框、4个启动子和2个增强子,基因组开放读码框相互重叠,所有转录调控元件均隐含在基因编码序列中,病毒DNA序列达到高效重复利用。而HBV新的调控元件和正链转录体,以及转录后调节元件的发现,则为以后的研究提供了新的思路。

Hepatitis B virus genome is constructed of a 3.2 kb-long circular DNA, including 40RFs, 4 promotors and 2 enhancers. The overlaped ORFs and the transcription regulatory elements implied in ORFs result in highly repeatedly utilization of virus DNA. The discovery of transcript from HBV plus strand and novel regulatory elements and post-transcriptional regulatory element highlight the direction for further research.