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脂肪间充质干细胞向心肌细胞分化的研究进展 被引量：1

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摘要 心肌梗死后心肌细胞发生坏死，但由于心肌干细胞的数目微乎其微，且代谢非常缓慢，难以对坏死心肌起到内源性的修复作用，只能通过纤维组织增生、瘢痕组织形成修复坏死部位，而存活的心肌细胞代偿性肥大，发生心室重塑，心功能下降，最终发展为缺血性心力衰竭，而成为死亡的主要原因。心脏移植虽可用外界干预方法有效改善患者的临床预后，提高生存率，但由于供体少、价格昂贵、存在免疫排斥等问题在临床应用受到限制。近年来，将体外纯化、培养增殖的心肌细胞或非心肌细胞移植到受损心肌组织中替代纤维组织以解决心肌细胞数量的减少，
作者 王建飞 郑显东
机构地区 解放军总医院心内科博士研究生 河北医科大学神经外科硕士研究生
出处 《中国医师进修杂志（内科版）》 2008年第3期73-74,共2页 Chinese Journal of Postgraduates of Medicine
关键词 脂肪间充质干细胞 心肌梗 细胞分化 心肌细胞移植 纤维组织增生 缺血性心力衰竭 坏死心肌 瘢痕组织形成
分类号 R681 [医药卫生—骨科学] R542.22 [医药卫生—心血管疾病]
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参考文献15

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二级参考文献34

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中国医师进修杂志（内科版）
2008年 第3期

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