CD44V6和β-catenin与骨肉瘤关系的研究进展

Expressions of CD44V6 and β-catenin in osteosarcoma and their clinical significance

CD44V6与β-catenin是两种重要的细胞黏附分子(cell adhesion molecules,CAMs),通过介导细胞与细胞、细胞与基质间的相互作用,参与多细胞生物的多种生理及病理过程,是近年来研究的热点。CD44V6主要分布于上皮源性细胞和肿瘤细胞,介导异质细胞间的黏附,与细胞的集聚、淋巴细胞的再循环、淋巴细胞的激活、细胞的迁移、细胞间的信号传导及肿瘤细胞的侵袭、转移密切相关;β-catenin介导同质细胞间的黏附,在脊椎动物的身体形成和发育及肿瘤的发生、发展及侵袭转移过程中起重要作用。已有研究证明,CD44V6、β-catenin在多种恶性肿瘤如骨肉瘤、乳腺癌、胃癌及结直肠癌中表达增高,其表达水平与肿瘤细胞的浸润、转移能力成正相关。因此,CD44V6与β-cate-nin能反映肿瘤细胞的增殖活性及肿瘤的恶性程度,可以作为肿瘤恶性表型的标志,尤其可以作为肿瘤的辅助性诊断及预测转移的指标之一。

CD44V6 and β-catenin are currently viewed as two important adhesive molecules that mediate the interaction of cell with cell, and cell with matrix,and affect various physiologic and pathologic processes. CD44V6 locates mainly at epitheliod and tumor cells, and may play an important role in some processes,such as cell adhesion, aggregation, lymphocytic recirculation and activation, cell migration, signal transduction and the metastasis of tumor cells. β-catenin has been proved to promote the cell adhesion, invasion and metastasis of some cancers, meanwhile, overexpress in many tumors including osteosarcoma, breast carcinoma, digestive tract cancers. These results suggest, therefore, CD44V6 and βcatenin may be taken as tumor markers that reflect proliferation activity and progression of cancer cells, and predict the prognosis of tumors.