骨髓增生异常综合征和急性白血病患者骨髓巨核细胞质与量变化的探讨

Study of qualitative and quantitative changes of megakaryocytes on myelodysplastic syndrome and acute leukemia

本文对124例MDS和136例AL患者的骨髓象巨核细胞计数及形态改变观察结果进行了分析。结果表明，MDS巨核细胞以增多组为主，巨核细胞质的改变与预后有关，易发展成AL，而且多数为粒／单核细胞系统受累．ANLL巨核细胞质与量的异常明显高于ALL。初发时巨核细胞计数增高及出现病态变化者缓解率低，预后不良。

In this paper, the cellular count and morphologic change of bone marrow megakaryocytes in 124 pa-tients with myelodysplastic syndrome (MDS) and 136 patients with acute leukemia (An) were analyzed. The result showed that the number of megakaryocyte was usually higher in MDS than that in normal individuals,and the patients with dysmegakaryopoiesis had poor prognosis. Dysplasia of both quality and quantity of megakaryocytes was more significant in patients with ANLL than that in ALL patients. Newly diagnosed patients with higher celluler count of megakaryocytes and dysmegakaryopoiesis had less complete remission rate and poor prognosis.