缺血性中风患者抗凝与纤溶系统的变化

Clinical study on anticoagulant and fibrinolytic system in ischemic stroke patioents

为研究缺血性中风患者抗凝及纤溶系统功能的改变，本文应用包括分子标志物凝血酶-抗凝血酶，纤溶酶-抗纤溶酶在内的系列新颖指标对患者组进行了测定。结果显示缺血性中风组蛋白C、蛋白S、α2-抗纤溶酶、纤溶酶原、抗凝血酶III活性降低、纤维蛋白原、D-二聚体、凝血酶-抗凝血酶、纤溶酶-抗纤溶酶升高，提示缺血性中风患者存在着凝血，纤溶功能的亢进和抗凝功能的抑制。

In order to study the changes of anticoagulant and fibrinolytic system in ischemic stroke patients,a se-ries of variables were assayed,including two newly-developped molecular markers: thrombin-antithrombin complex and plasmin-α2-antiplasmin complex. The results showed that both the activity and antigen level of protein C, protein S and α2-antiplasmin, the activity of plasminogen and antithrombin III decreased, while the level of fibrinogen, d-dimer, thrombin-antithrombin complex and plasmin-α2-antiplasmin complex in-creased, indicating that ischemic stroke patients do exist abnormal elevation of coagulant and fibrinolytic function, as well as the inhibition of anticoagulant function.