急性吗啡染毒大鼠脑内吗啡的形态学观察

THE DISTRIBUTION OF MORPHINE IN BRAIN TISSUE OF MORPHINE TREATED RATS

用免疫组织化学法对急性吗啡染毒大鼠脑内吗啡的分布进行研究。结果表明，吗啡存在于人脑的前连合、外侧嗅束、海马伞、胼胀体、扣带、穹隆；间脑的丘脑终纹、丘脑网状核、乳头丘脑束；脑干的脑桥横纤维、锥体束、脚间核；小脑髓质和脊髓白质中。注射吗啡10分钟后即可在脑少数部位出现吗啡。本研究为吗啡研究提供了形态学基础，并为吗啡染毒者的诊断提供了一个新的依据。

This study dealed with the distribution of morphine in brain tissue of morphine treated rats by us-ing the methods of immunohistochemistry (PAP). The distribution of morphine in brain tissue at thedifferent time after morphine treatment was observed systemtically. Morphine was found in anteriorcommissure, lateral olfactory tract,fimibria of the hippocampus,callosum,cingulum, fornix stria terrni-nalis of thalamus,reticular thalamis nucleus, mammillothalamic tract, pontine transversae fibrae, pyra-midal tract, interpeduncular nucleus, cerebellar white matter of cevebellum and spinal cord. Few re-gions in the rat's -brain were positive at 10min after injection of morphine. The present study providesthe characteristics of the morphine distribution after morphine treatment and a new method for detect-ing morphine in morphine addicts.