摘要
为观察前列环素(PGI_2)对皮瓣成活的影响,以大白鼠背部设计超长任意型皮瓣模型,设立术前(预防组)、术后(治疗组)静脉给 PGI_2及生理盐水对照组,对皮瓣的血供、代谢和血液流变学等进行分析。结果表明治疗组皮瓣远端血流相对值为41.3%,对照组为22.4%,治疗组皮瓣成活率明显高于对照组,预防组与对照组相比无明显差异。提示:术后早期给予 PGI_2可以改善皮瓣的血流和血液流变状态,提高皮瓣成活面积。
The purpose of this experiment was to observe the effect of PGI_2 on the survival of the random skin flap.White rats used in the experiment were divided into preoperation (prevention)group, postoperation (treatment)group and the control group.A super-long random skin flap was created on the back of the animal.Postoperatively,the treatment group received intravenous injection of PGI_2 while the control group received intravenous injection of normal saline.The blood supply,metabolism and hemorheology of the flap were analyzed.Results showed that the relative blood flow on the distal part of the flap was 41.3% in the tretment group and 22.4% in the control group.The survival rate of the flap of the treatment group was higher than that of the control.There were no differences between the pre- vention and the control groups.It is concluded that early postoperative injection of PGI_2 could improve blood supply and theology of the flap and increase its survival rate.
