临床常见病原菌的耐药分析

Antimicrobial susceptibility of common pathogen

目的了解近两年多来临床分离的常见病原菌对临床常用抗生素的耐药情况,为临床合理用药提供依据。方法用梅里埃公司生产的GP、GN鉴定卡及AST药敏分析卡对近两年多临床所有分离菌进行鉴定和药敏分析,统计临床常见病原菌对临床常用抗生素的耐药率。结果革兰氏阳性球菌对青霉素的耐药率很高,并呈逐年上升趋势,而加酶抑制剂的青霉素类合剂相对不加酶抑制剂的青酶素其耐药率明显减低,万古霉素对其耐率最低,但已出现了耐万古霉素肠球菌。革兰氏阴性菌对许多抗生素的耐药率也呈上升趋势,亚胺培南对其活性最高。结论本院近年常见病原菌的耐药鉴测分析结果显示临床分离的耐药性已相当严重,并呈上升趋势,应引起临床上的重视。

Objective To study the resistance of clinical commonly seen isolated pathogen from 2005 to 2007 in order to offer the physicians the basis of using antibiotics reasonably. Methods Biomerieux Company＇s GN,GP,AST-vitek cards were used to identify the bactcria and detect antimicrobial and calculated the resistant rates to the antibiotics commonly used. Results The rats of penicillin-resistant Gram-positive bacteria were higher and higher, but penicillin with the emzyme-inhibitant sensitive to them. Vancomycin was still very sensitive to them. But Vanconycin-resistant entercocci had appeared. The negative bacteria resistance also increased year after year ,but Imipenem was very effective. Conclusions The resistance of microbe has come to be more and more serious, We must pay more attention to it.