乳腺癌组织中微血管定量及其意义

Quantitation of Microvessels in Breast Cancer and It's Significances

应用第Ⅷ因子相关抗原单克隆抗体ＡＢＣ免疫组化研究５０例原发性乳腺癌微血管定量及其意义。发现组织学分级Ⅰ级乳腺癌微血管定量明显低于Ⅱ级或Ⅲ级，癌胚抗原阴性乳腺癌微血管定量明显低于癌胚抗原阳性乳腺癌，淋巴结转移组乳腺癌微血管定量明显高于淋巴结未转移组乳腺癌；微血管定量与乳腺癌雌二醇受体（ＥＲ）、黄体酮受体（ＰｇＲ）状态及其它临床病理特征无明显关系。提示乳腺癌组织中微血管生成与其组织学分级有密切关系，高微血管定量乳腺癌易发生区域淋巴结转移。

The quantitation of microvessels and its significances were investigated by immunohistochemical method of factor Ⅷ related antigen in 50 cases with breast cancer.The quantitations of microvessels were significantly lower in the cases of histologic I grade,without metastasis,and the negative of carcinoembryonic antigen than in the cases of histologic Ⅱ or Ⅲ grade;with metastasis,and the positive of carcinoembryonic antigen.These results suggested the angiogenesis in breast cancer tissue might be related to histologic grades,the breast cancer with highly quantitation minght be inclined to metastasis and have poorer prognosis.