山东地区汉族关节病型银屑病与HLA-DRB1、DQB1的相关性研究

Study on the association between HLA-DRB1,DQB1 genes and psoriatic arthritis in Han Shandong Province

目的:探讨HLA-DRB1、DQB1位点基因与关节病型银屑病的相关性。方法:用序列特异性引物-聚合酶链反应(PCR-SSP)方法,对41例关节病型银屑病患者进行了HLA-DRB1、DQB1等位基因的分型,并分析了上述基因在各组中的分布。结果:关节病型银屑病患者组DRB1*07、DQB1*0201频率较正常对照组增高;多关节炎型银屑病患者组DRB1*07、DQB1*0201以及DRB1*04基因频率比正常对照组显著增高。结论:HLA-DRB1*07、DQB1*0201可能是山东地区汉族关节病型银屑病的遗传标志;具有银屑病易感基因的个体,携带HLA-DRB1*04基因时,患多关节炎型银屑病的危险性可能增加。

Objective： To investigate the predisposing alleles of HLA - DRB1, DQB1 genes in psoriatic arthritis. Methods： Polymerase chain reaction - specific sequence primers （PCR - SSP） method was used to type HLA - DRB1, DQB1 subregion in 41 cases with psoriatic arthritis and matched control subjects of Han nationality in Shan- dong province. Results： The frequency of HLA - DRB1 ＊ 07, DQB1 ＊ 0201 allele in psoriatic arthritis patients was significantly higher than that in controls and DR4 in patients with psoriasis polyarthritis was significantly higher than that in controls. Conclusion： The results suggest that HLA- DRB1 ＊ 07 and HLA - DQB1 ＊ 0201 may be the susceptible alleles of psoriatic arthritis in Han Chinese.