异丙酚麻醉下胃镜检查患者血压、心率及血浆一氧化氮、内皮素变化

Study the safety of propofol for painless gastroscopic examination

目的研究异丙酚麻醉下无痛胃镜检查对患者血液动力学影响。方法选择2003年3月至2003年5月门诊胃镜检查患者60例,随机分为两组,每组30例。无痛组静脉推注异丙酚2.0mg/kg麻醉后检查,对照组行常规胃镜检查。观察2组患者检查前后血浆一氧化氮(NO)、内皮素(ET)及检查前、中、后血压、心率的变化。结果对照组于检查前后血浆NO、ET水平的变化有明显差异(P<0.05),而无痛组则无明显差异。对照组于检查中心率和收缩压的变化幅度较大,与无痛组相比有显著性差异(P<0.05)。结论异丙酚用于无痛胃镜检查对血液动力学影响更小,是一种安全的检查方法。

Objective To observe the impact of propofol for painless gastroscopic examination on hemodynamics. Methods 60 cases were divided into 2 groups,30 cases undertaking propofol,30 cases undertaking routine procedures,observed and the blood pressure, heart rate and serum nitric oxide （NO）, serum endothelins（ET） of patients during the gastroscopy were recorded. Results The blood serum NO and ET level show no difference before and after the painless gastroscopy examination （P 〉 0. 05 ） , whereas there are differences in routine procedure group （P 〈 0.05 ）. Distinct variances of HR and SBP of routine procedure group is recorded, differs from that of the painless gastroscopy group （ P 〈 0.05 ）. Conclusion Propofol for Painless gastroscopy examination imposes little impact on hemodynamics,it proves to be a safe method.