多肿瘤标志物蛋白芯片在消化道肿瘤中的检测及临床意义

Multipe tumor markers protein biochip in detection of digestive tract cancer and its clinical significance

目的探讨多肿瘤标志物蛋白芯片在消化道肿瘤中的检测及其临床意义。方法用该蛋白芯片测定系统测定56例消化道恶性肿瘤患者、32例消化道良性疾病患者和48例健康对照者血清中12种常规肿瘤标志物(CA199、NSE、CEA、CA242、Ferritin、β-HCG、AFP、Free-PSA、PSA、CA125、HGH及CA153)的水平。结果消化道恶性肿瘤组的阳性率为76.79%,显著高于良性疾病组(25%)和健康对照组(8.33%)(P<0.05)。结论多肿瘤标志物蛋白芯片检测系统可以显著提高消化道肿瘤诊断的敏感性。

Objective To evaluate the clinical sinificane and detection of multi - tumor markers protein biochip for digestive tract cancer. Methods The serum levels of 12 common tumor markers,including CA199 、NSE ,CEA 、CA242,Ferritin 、 β -HCG ,AFP ,Free- PSA 、PSA ,CA125 ,HGH and CA153, were measured with the detective system in 56 digestive tract cancer patients,32 patients with benign digestive disease and 48 healthy examinations. Results The positive rates were 76.79% -25% and 8.33% in digestive tract cancer, benign digestive disease and healthy groups, respectively. The digestive tract cancer group had significantly higher positive rate than that of the controls （ P 〈 0.05 ）. Conclusion Multi - tumor markers protein biochip can significantly increase the diagnostic sensitivity for digestive tract cancer.