氟西汀配合康复训练治疗脑卒中后抑郁的临床研究

Effect of Fluoxetine with Rehabilitation on Poststroke Depression

目的:观察氟西汀配合康复训练治疗脑卒中后抑郁的临床疗效。方法:87例脑卒中后抑郁患者分为康复组45例和对照组42例,均每日口服氟西汀20 mg,康复组患者同时配合康复治疗;分别于治疗前后对2组进行Barthel指数(BI)、Fugl-Meyer运动量表(FMMS)、Zung抑郁自评量表(SDS)和汉密尔顿抑郁量表(HAMD)检测。结果:治疗3个月后,2组SDS、HAMD评分与治疗前比较减分明显,BI、FMMS评分明显上升(均P<0.01);2组间比较康复组显示更明显(P<0.05)。抑郁状态比较,康复组SDS及HAMD总有效率明显高于对照组(77.8%、78.6%与60.0%、52.4%,P<0.05和0.01)。结论:氟西汀配合康复训练治疗脑卒中后抑郁有明显的临床疗效。

Objective： To observe the effect of fluoxetine with rehabilitation on poststroke depression. Methods： Eight seven stroke patients with hemiplegia were divided into the rehabilitation group （45 cases） and control group （42 cases）. All patients in both two groups were administered with fluoxetine （20 rag/day）, and the patients in the rehabilitation group were subjected to regular rehabilitation additionally. All patients were evaluated with Bathel Index （BI）, Fugl- Meyer Motor Scale （FMMS）, Zung Self-rating Depression Scale （SDS） and Hamilton Depression Scale （HAMD） before and 3 months after treatment. Results：After treatment for 3 months, the scores of SDS, HAMD, BI and FMMS in both two groups were increased significantly as compared with those before treatment （P〈0. 01）, and the scores of SDS, HAMD, BI and FMMS in the rehabilitation group after treatment was also increased significantly as compared with those in the control group after treatment （P〈0.05）. Conclusion：Fluoxetine with the rehabilitation can obviously decrease de pression of stroke patients with hemiplegia.