喹硫平（舒思）治疗老年痴呆患者精神行为症状的疗效分析

Effect of Quetiapine （Shusi） on behavioral and psychological symptom of dementia in the elderly

目的观察喹硫平（舒思）治疗老年痴呆患者精神行为症状（BPSD）的疗效。方法对30例老年痴呆伴精神行为症状（BPSD）患者使用舒思治疗8周，采用神经精神科问卷（NPI）评定疗效。结果舒思治疗后BPSD明显减轻，有效率93．3％；NPI各项因子分除欣快、情感淡漠／漠不关心外均明显改善；照料者的苦恼程度随BPSD的减轻而降低。结论舒思治疗老年痴呆BPSD疗效肯定，有效治疗剂量小，安全性高，同时能减轻照料者的苦恼程度。

Objective To investigate the effect of Quetiapine （Shusi） on behavioral and psychological symptom of dementia （BPSD） in the elderly. Methods Thirty patients diagnosed as dementia accompanied with BPSD had been treated with Quetiapine （Shusi） for 8 weeks, then therapeutic effect was assessed by questionnaire of Neuropsychiatric Inventory （NPI）. Results The total score of NPI significantly decreased after treatment and the effective rate arrived to 93.3%. All of the symptoms were significantly relieved except euphoria and apathy. The score-reduced rate of caregivers＇ distress was positively associated with the scorereduced rate of NPI of relative patients. Conclusions There was a significant safety and effectiveness of the low dose Quetiapine （Shusi） on dementia patients with BPSD, which can relieve caregivers＇ distress.