β-环糊精修饰超氧化物歧化酶的代谢动力学研究

Study on Pharmacokinetics of β-Cyclodextrin Modified Superoxide Dismutase

牛血铜，锌-超氧化物歧化酶（Cu，Zn－SOD）用高碘酸钠活化的β-环糊精（β-Cyclodextrin，β-CD）修饰。对修饰酶静脉注射兔体进行药代动力学研究，结果表明β－CD修饰的SOD在兔体内基本符合二室模型，其特征方程为C＝236e－7.0937t＋60e-0.4473t，修饰SOD的T为0．11±0．04h和1．66±0．48h，体内CLB为53±11．10L／（kg·h），曲线下面积AUC为176．5±35．40U（L·h）。

Bovine Cu, Zn-superoxide dismutase (Cu, Zn-SOD) was modified with NaIO4 activated β-cyclodextin (β-CD). The pharmcokinetics of the modified enzyme was studied and the result suggested that the concentration-time data fit two compartment model when the enzyme was injected intravenously into rabbits. The fomular of the pharmacokinehcs was C= 236e-7.093 7t+ 60e-0.447 3t, the T and 71 were 0. 11 ±0. 04 h and 1. 66±0. 48 h, CLB 53± 11. 10 L/(kg·h), and AUC 176. 5±35.40 U/(L· h).