滋肾柔肝冲剂治疗慢性乙型肝炎及肝纤维化的临床研究

The clinical study of treating chronic hepatitis B and hepatofibrosis with Zishen Rougan Granule

目的:探讨慢性乙型肝炎及肝纤维化的中医药疗法。方法:同期临床随机对照观察,对119例慢性乙型肝炎用纯中药制剂“滋肾柔肝冲剂”治疗,对照组117例用纯中药制剂“乙肝养阴活血冲剂”治疗。结果:临床症状、肝功能、病毒复制指标、肝纤维化4项指标(Ⅳ型胶原、透明质酸、PⅢP、板层素)的改善,观察组均比对照组为优,统计学上有明显差异。结论:“滋肾柔肝冲剂”是治疗慢性乙型肝炎较好的药物。

Aim: To study the traditional chinese medical therapy of chronic hepatitis B and hepatofibrosis. Methods: 119 cases of chronic hepatitis B treated with Zishen Rougan (ZRG ), with 117 cases treated with Yigan Yangyin Huoxue Granule (YYHG) as control group. Both granules were pure Chinese, herb medicines and the patients were divided into two groups randomly. Results: The results show that clinical symptoms, Liver function, duplication of virus and the four indexes of hepatofibrosis (collagen type Ⅳ , hyaluronic acid, PⅢP, laminin ) of the observation group were better than those of the control group. Conclusion: ZRG is a better medicine to treat chronic hepatitis B.