放化疗对肿瘤患者血小板参数的影响及意义

The Influence of Radiotherapy and Chemotherapy on Platelet Parameters in Tumor Patients and Its Significance

目的:探讨肿瘤患者放化疗前及放化疗后血小板参数的变化和临床意义。方法:用SF-3000全自动五分类血液分析仪测定31例肿瘤患者放化疗前及放化疗后静脉血的血小板数(PLT)、血小板比积(PCT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)和大体积血小板比率(P-LCR),并与正常对照组比较。结果:肿瘤病人治疗前各参数与正常对照组间比较无显著性差异(P>0.05),而PLT、MPV、PCT、P-LCR在放化疗后患者组均明显低于放化疗前(P<0.01或P<0.05),PDW则与放化疗前无显著性差异(P>0.05)。结论:肿瘤放化疗患者血小板参数的测定对观察其骨髓抑制状况和病情估计有一定的临床意义。

Objective：To study the changes of platelet parameter in tumor patients before or after radiotherapy and chemotherapy and the clinic significance. Methods： 31 cases of tumor patients before or after radiotherapy and chemotherapy were selected and their platelet parameters（PLT, PCT, MPV,DPW, P-LCR） were measured by the sysmex SF- 3000 complete automatic hemanalysis, then compared with control group. Results： There was no signfieant difference between the two groups in the platelet parameters before radiotherapy and chemotherapy （P〉0. 05）. The levels of PLT, PCT, MPV, P-LCR in tumor patients after radiotherapy and chemotherapy were significantly lower than that before radiotherapy and chemotherapy（P〈0. 01 或 P〈0. 05）, but PDW is no different（P〉0. 05）. Conclusion： Determine of platelet parameters of tumor patients before or after radiotherapy and chemotherapy is of certain clinical significance for observation of the status of their marrow restrained and estimate of state of illness.