普伐他汀与烟酸肌醇单用和合用对高脂血症的疗效观察

The Effect of Pravachol,Inositoli Nicotinatis and Combining Treatment on Blood Lipid in Patients with Hyperlipidemia

为比较普伐他汀和烟酸肌醇单用和合用对高脂血症病人血脂的影响，将高脂血症患者分成普伐他订组、烟酸肌醇组和联合用药组，观察治疗前后血脂的变化。结果发现，晋代他汀组血清总胆固醇从7．0±1．4降至5．9±1．5mmol／L（P＜0．05），低密度脂蛋白胆固醇从4．6±1．3降至3．6±1．2mmol／L（P＜0．05），而甘油三酯无明显降伏。烟酸肌醇组甘油三酯从2．7±1．2降至2．1±0．9mmol／L（P＜0．05），而总胆固醇和低密度脂蛋白胆固醇无明显降低。两药治疗后高密度脂蛋白均无显著性变化（P＞0．05）。联合用药组治疗后血脂各项指标降低或升高的幅度均比普代他汀组和烟酸肌醇组大，总胆固醇分别降低27.3％、15.6％和7.5％（P＜0．05），甘油三酯分别降低31．9％、7．1％和22．8％（P＜0．05），高密度脂蛋白分别升高11．2％、1．7％和4．49％（P＜0．05）。单一治疗无效的39例高脂血症患者分别联用烟酸肌醇或普伐他汀，观察4周，发现血总胆固醇从6．5±1．4降至4.5±1．3mmol／L（P＜0．01），血甘油三酯从2．6±1．2降至1．9±1．lmmol／L（P＜0．01），高密度脂蛋白从1．16±0．22升至1．27±0．21mmol／L（P＜0．05）。提示普代化汀加烟酸肌醇联合治疗可增强降脂效果，改善血脂组成。

Aim To examine the effect of sole or combining treatment of pravachol and inositoli nicotinatis on blood lipid in patients with hyperlipidemia.Methods 72 cases with hyperlipidemia were divided into pravachol group, inositoli nicotinatis group and combining treatment group. Treatment period lasted for 4 weeks,blood lipid parameters were measured before and after treatment.Results After treatment pravachol significant cend the levels of TC and LDLC, doesn't descend TG (TC: 7.0 ±1.4vs 5.9mmol/L, P<0. 05; TG: 2. 7±1.2vs 2.5±1.0 mmol/L, P<0.05; LDLC: 4.6 ±1.3vs 3.6±1.2mmol/L, P<0.05), inositoli nicotinatis significant reduce TG, doesn't descend TC,LDLC (TC: 7.0±1.4vs 6.4±1.5mmol/L, PRO.05; TG: 2.7±1.2vs 2.1±0.9mmol/L, P<0.05; LDLC: 4.6±1.2vs 4.3±1.3mmol/L, P<0.05).Decreased or increased magnitude of blood lipid composition in combining group were greater than those in pravachol group and inositoli nicotinatis group (TG:- 27.3%, -15. 6% and -7.5%, P<0. 05; TG:- 31.9%,-7.l% and -22.8%, P<0.05; HDL: +11.2%, +l.7% and +4.4%,P<0. 05). 39 cases that sole treatment was not effective received combining treatment for another 4 weeks, blood lipid composition have furture changed (TG:6.5±1.4 vs 4.5±1. 3mmol/L,P<0.01; TG: 2.6±1. 2 vs 1. 9±1. 1 mmol/L,P<0. 01; HDL: 1. 16±0. 22 vs 1.27f±21 mmol/L,P<0.05).Conclusion These data suggest that combining pravachol with inositoli nicotinatis treatment can enhance the reducing blood lipid effect, improving blood lipid composition.