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鼻窦肿瘤相关的低磷抗维生素D骨软化症一例 被引量：4

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摘要 患者女，49岁，以进行性全身无力、腰背四肢疼痛6年，加重8个月入我院内分泌科治疗。患者6年前开始无明显诱因出现双下肢无力，腰背部疼痛明显，当时未能明确病因。5年前发现鼻腔肿瘤，行手术切除（术后被告知为良性肿瘤，具体不详），术后症状消失。术后18个月再次出现上述症状，渐加重。近8个月来行走及生活自理能力受到影响。胸廓变形，伴心慌气短等症状。
作者 亓放 王晓巍
机构地区 中国医学科学院 中国协和医科大学 北京协和医院耳鼻咽喉科
出处 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2008年第3期228-229,共2页 Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词 低磷抗维生素D 骨软化症 肿瘤相关 腰背部疼痛 鼻窦 生活自理能力 双下肢无力 全身无力
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献12

  • 1Muror H, Hernando N, Forster I, et al. Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol Rev, 2000, 80: 1373-1409.
  • 2Shimada T, Urakawa I, Yamazaki Y, et al. FGF-23 transgenie mice demonstrate hypophosphatemie tickets with reduced expression of sodium phosphate eotransporter type Ⅱa. Biochem Biophys Res Commun, 2004, 314: 409-414.
  • 3Jonsson KB, Zahradnik R, Larsson T, et al. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med, 2003, 348: 1656-1663.
  • 4Shimada T, Kakitanl M, Yamazaki Y, et al. Targeted ablation of FGF-23 demonstrate an essential physiological role of FGF-23 in phosphate and vitamin D metabolism. J Clin Invest, 2004, 113: 561-568.
  • 5Shimada T, Mizutani S, Muto T, et aL Cloning and characterization of FGF-23 as a causative factor of tumor induced osteomalacia. Proc Nath Acad sci USA, 2001, 98: 6500-6505.
  • 6Folpe AL, Fanburg-Smith JC, Billings SD, et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity : an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol, 2004, 28: 1-30.
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  • 9钟定荣,刘彤华,杨堤,冯瑞娥,崔全才,罗玉凤,贾勇.骨软化或佝偻病相关的间叶组织肿瘤临床病理分析[J].中华病理学杂志,2005,34(11):724-728. 被引量：24
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二级参考文献15

  • 1Folpe AL, Fanburg-Smith JC, Billing SD, et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity:an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol,2004,28 : 1-30.
  • 2Evans DJ, Azzopardi JG. Distinctive tumours of bone and soft tissue causing acquired vitamin-D-resistant osteomalacia. Lancet, 1972, 1 :353-354.
  • 3张孝骞 朱预 刘彤华.间叶瘤合并抗维生素D的低血磷软骨病一例报告[J].中华医学杂志,1980,60:150-152.
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  • 6Asnes RS, Berdon WE, Bassett CA. Hypophosphatemic rickets in an adolescent cured by excision of a nonossifying fibroma. Clin Pediatr ( Phila), 1981,20 : 646 -648.
  • 7Ben-Baruch D, Ziv Y, Sandbank J, et al. Oncogenic osteomalacia induced by schwannoma in a patient with neurofibromatosis. Eur J Surg Oncol, 1994,20 : 57-61.
  • 8Bowe AE, Finnegan R, Jan de Beur SM, et al. FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem Biophys Res Commun ,2001,284:977-981.
  • 9Cehreli C, Alakavuklar MN, Cavdar C, et al. Oncogenous osteomalacia: report of a case. Acta Oncol, 1994,33:975-976.
  • 10Clunie GP, Fox PE, Stamp TC. Four cases of acquired hypophosphataemic ( oncogenic ) osteomalacia. Problems of diagnosis, treatment and long-term management. Rheumatology( Oxford), 2000,39 : 1415-1421.

共引文献23

同被引文献32

引证文献4

二级引证文献2

中华耳鼻咽喉头颈外科杂志
2008年 第3期

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