肝癌切除缘注射纯酒精并化疗对复发的影响

Effects of combined cutting_edge anhydrous alcohol injection and chemotherapy on postoperative recurrence of primary liver cancer

目的研究原发性肝癌（肝癌）切缘纯酒精注入配合术中、术后经全埋式药物输注装置（ＤＤＳ）化疗对肝癌复发率的影响．方法肝癌３７例（Ｂ组）切除术在肝切缘用纯酒精４０ｍｌ多点注射；肝动脉植入ＤＤＳ后于术中、术后以ＦＭＣ方案化疗４疗程，并与４６例（Ａ组）单纯切除的肝癌病例比较１及２年的复发率．结果随访１年时，Ａ组的复发率为３７８％，Ｂ组为７１７％，两组比较差异非常显著（Ｐ＜００）；２年时Ａ组复发率为７５６％，Ｂ组为９３５％，两组比较差异有显著性（Ｐ＜００５）．结论纯酒精肝切缘注入配合术中、术后化疗可降低肝癌术后的复发率．

AIM To study the effects of combined cutting_edge anhydrous alcohol injection and chemotherapy through drug delivery system (DDS) on postoperative recurrence of primary liver cancer(PLC). METHODS From January 1990 to January 1995, 83 patients with PLC were divided into two groups, Group A: hepatectomy only (46 cases); Group B: combined resection and cutting_edge anhydrous alcohol injection plus FMC regimen chemotherapy for four courses (37 cases) during and posthepatectomy through DDS and followed up for two years. RESULTS An obvious difference was found ( P <0 01) between groups A (37 8%) and B (71 7%) in postoperative recurrence of PLC for one year. The recurrence rate in group A (75 6%) was lower than that in group B(93 5%) for two years(0 01< P <0 05). CONCLUSION Combined cutting_edge anhydrous alcohol and DDS chemotherapy after hepatectomy is useful in preventing postoperative recurrence.