原发性高血压、冠心病患者尿微量白蛋白阳性率及其相关因素

Importance of detection of microalbuminuria in patients with primary hypertention and coronary heart disease

目的:探讨微量白蛋白尿与原发性高血压和冠心病的关系。方法:采用酶标记抗原一步竞争法,检测81例原发性高血压患者、66例冠心病患者及108例健康对照的尿微量白蛋白。结果:原发性高血压患者尿微量白蛋白阳性率为54.3%,冠心病患者尿微量白蛋白阳性率为37.9%,高血压患者尿微量白蛋白与收缩压及高密度脂蛋白相关,尿微量白蛋白阳性冠心病患者发生急性心梗和尿微量白蛋白阴性冠心病患者发生急性心梗分别为40%和17.1%(P<0.05)。结论:冠心病尿微量白蛋白阳性患者预后不良,提示尿微量白蛋白测定的重要性。

Objective：To investigate the relationship among microalbuminuria（MAU）,primary hypertention and coronary heart disease（CHD）.Methods：The levels of MAU were determined by enzyme linked immunosorbent assay（ELISA） in 81 primary hypertensives,66 CHD and 108 healthy controls.Results：The positive MAU in primary hypertensives was 54.3% and the positive MAU in CHD was 37.9%.MAU in hypertentives was associated with systolic blood pressure（SBP） and high density lipoprotein cholesterol（HDL-C）.The occurring rate of myocardial infarction in MAU positive CHD was significantly higher than that in MAU negative CHD（40% and 17.1%,P〈0.05）.Conclusion：MAU is significantly associated with the progression of CHD.It is important to detect urine microalbumin in patients with primary hypertention or CHD.