脾脏切除对胸腺和淋巴结免疫功能的影响

EFFECT OF SPLENECTOMY ON THYMOCYTE AND LYMPHONODI CELL FUNCTIONS

报道脾脏切除（脾切）对动物胸腺和淋巴结免疫功能的影响。脾切后３ｗ大鼠胸腺细胞自发增殖及ＣｏｎＡ诱导增殖均无明显变化，ＣｏｎＡ诱导淋巴结细胞增殖脾切组明显高于假手术对照组。脾切后３ｗ，再用ＳＲＢＣ免疫，５ｄ后小鼠腹腔淋巴结数量脾切组明显高于对照组，用ＱＨＳ法测定淋巴结细胞对ＳＲＢＣ初次抗体产生脾切组则明显低于对照组。

Effect of splenectomy on thymocyte and lymphonodi cell function was studied.Splenectomy was performed on Wistar rats and NIH mice of 5～6 days of age,3 weeks later,immune functions were measured.The results were as follows:Rat thymocyte spontaneous proliferation and ConA induced thymocyte proliferation were no obvoius changes;ConA induced lymphonodi cell proliferation was increased in the splenectomy group(P<0 05);Lymphonodi cell numbers were increased in splenectomy group(P<0 05);The ability of antibody producing for SRBC in splenectomy group was decreased(P<0 02) compared with that of sham operation controls.