P_(53)基因表达与胃癌生物学行为的关系

P_(53) expression and it's prognostic significance in carcinoma ventriculi

采用免疫组织化学方法对55例胃癌组织作抗癌基因──P53基因蛋白的异常表达研究。结果显示：P53基因蛋白的表达频率和水平与组织浸润程度呈高度相关性，浸润粘膜下层时呈阴性表达（64．52％）或低水平表达（32．25％），浸润至浆膜时则均呈过度表达；P53基因蛋白的表达与淋巴结转移数呈显著正相关。提示对P53基因表达的研究有助于胃癌预后评估。

Purpose: To approach the relationship between P53 expression and biologic behavior and to evaluate the prognostic significance of P53 expression in carcinoma ventriculi. Methods: Immunohistochemical methods were used in this study to detect P53 abnormal expression in paraffin-embedded sections of 55 carcinoma ventticuli cases. Results and Conclusion: The total opitive rate of P53 immunostaining was 60%. The deeper tissue infitrated and the more lymphnods transfered, the higher frequency and intensity of P53 expression. There were statistically significant correlation P53 expression with carcinoma ventriculi, and as a prognostic indicator it was valuable for clinical practice.