摘要
增殖细胞核抗原（ｐｒｏｌｉｆｅｒａｌｉｎｇｃｅｌｍｕｃｌｅａｒａｎｌｉｇｅｎ，ＰＣＮＡ）在乳腺癌组织中表达的研究，表明在癌组织中ＰＣ－ＮＡ阳性细胞百分比越高生存期越短，生存期随百分比下降而延长，说明ＰＣＮＡ与乳腺癌近期复发率、死亡率有明显相关性。而癌胚抗原（ＣＥＡ）的表达与生存期无明显相关性，通过对３０例的研究结果认为ＰＣＮＡ表达对判断乳腺癌的预后有重要价值。ＰＣＮＡ在细胞内的含量，反映了细胞的增殖状态，当ＰＣＮＡ在肿瘤细胞内含量高时，细胞增生活跃，倍增时间短；肿瘤细胞的生物学特征表现为细胞分化程度低，恶性程度高，组织侵袭力强，复发及远处转移早，临床预后差。
We studied 30 cases of breast cancer PCNA (proliferatingcell nuclear antigen) and CEA measuring and analysised the relation of PCNA expression and postoperation survivat duration The results showed that centigrade ratio overexpression PCNAcell may imply that the higher PCNA contents is, the shorter postoperative survival duration is. there is a negative relation between PCNA value and survival duratiom and PCNA values are significanfly different among the groups of survival (6-12month, 48-60month andmore than 10 years). this suggests that PCNA may be considered as a useful indicator for breast cancer prognosis and electrical chemical-therapy. It is not connected with CEAexpression in postoperative survival duration of Breast cancer patients.
