摘要
使用ｐ５３突变蛋白单克隆抗体，采用免疫组化ＡＢＣ法，对９３例乳腺癌标本的石蜡包埋切片进行标志，藉此探讨ｐ５３突变蛋白与乳腺癌生物学行为之间的关系，结果显示：ｐ５３突变蛋白在乳腺癌中的阳性率是４７．３１％，非特殊型和特殊型乳腺癌的ｐ５３突变蛋白阳性率分别为４７．６７％和４２．８６％，二者无显著差异。ｐ５３突变蛋白阳性率与肿瘤分期、月经状况以及淋巴转移状况无关。
We used P53 mutant Protein′s monoclonal antibody and immunohistochemistry ABC methods to mark the Paraffin-section of 93 cases′ breast cancer specimen in order to study the relationship between P53 mutant protein and breast cancer biological behavior.the result is that,the positive rate of P53 mutant Protein is 47.31% in breast cancer and the rate is 47.67% in non-specific breast cancer,while 42.86% in specific breast cancer.There is no significant difference.The positive rate of P53 mutant protein is irrelevant to tumor grade and size, menstruation and lymph nodal metastasis.
