摘要
根据腺管形成、细胞分化及核分裂相将乳腺癌分为三级；浆细胞反应以每个毛细淋巴管周围浆细胞数在５个以上为阳性，基底膜破环与弹力纤维反应也分为三级。观察１４５例乳腺癌，结果发现：乳腺癌Ⅰ级５９例，其中浆细胞反应阳性３８例，占６４．４％；乳腺癌Ⅱ级６７例，浆细胞反应阳性３０例，占４４．８％；乳腺癌Ⅲ级１９例，浆细胞反应阳性４例，占２１．１％。说明浆细胞反应阳性与乳腺癌分级数呈负相关。而各级乳腺癌中，浆细胞反应阴性病例的淋巴结转移分别为６６．７％，６８．４％，７８．５％，说明浆细胞反应程度直影响乳腺癌的淋巴结转移。纤维反应（＋）者１３例，淋巴结阳性３例，占２３．１％，纤维反应（＋＋）者５２例，淋巴结阳性２８例，占５３．８％；纤维反应（＋＋＋）者５９例，淋巴结阳性３５例，占６９．５％。淋巴结转移率与纤维反应分级数呈正相关，从而提示：乳腺癌基底膜破环，弹力纤维增生、变性、固缩均可作为乳腺癌的预后指标。
According to glandular structures,cell differentiation and nuclear mitosis of the cancer cells,breast cancer was separated into three grades.Plasmacyte reaction positive is that the number of Plasmacytes in a lymphatic Capillary over five.We separate basement membranes Severance and elastic fiber reaction into three grades too. Total 145 cases of breast cancer were separated into three groups:Grade 1 of breast cancer is 59 cases,Plasmacyte reaction positive 38 cases,(64.4%).Grade 2 is 67 cases,Plasmacyte reaction positive 80 cases,(44.8%).Grade 3 is 19 cases,plasmacyte reaction positive 4 cases,(21.1%).It is suggested that there is a negative correlation between plasmacyte reaction positive rate and grades of breast cancer.Among all grades of breast cancer,the lymph node metastases rate in the cases of plasmacyte reaction negative was grade 1,66.7%;grade 2,68.4%;grade 3,78.5%,three rates are over 49.7%.It is suggested that plasmacyte reaction in capillary lymphatic vessel and lymph node metastases of breast cancer are a strong reaction. In all 145 cases breast cancer fiber reaction(+)was 13 cases,lymph a node metastases cases,23.1%;fiber reaction(++)52 cases,lymph node metastases 28 cases,53.8%;fiber reaction(+++)59 cases,lymph node metastases 41 cases,69.5%.Lymph node metastases rate was directly proportional to grades of fiber reaction.our results show that basement membranes severance and proliferation,degeneration suggested the prognosis of breast cancer.
