TGF-β促纤维化机制及中药干预的研究进展

Study on the progress of the mechanism of TGF-β in the scarring and the effect of TCM

转化生长因子(TGFβ)是影响伤口愈合与瘢痕形成的重要生物因子,它能促进细胞增殖、迁移、分化和凋亡,同时刺激细胞外基质沉积和胶原过度产生。TGFβ的生物作用受到很多相关因子的调节(核心蛋白聚糖、结缔组织生长因子等)。中药治疗纤维化及瘢痕有其独特疗效,在减少瘢痕的同时能加速伤口愈合。越来越多的实验证实单味中药或中药复方能通过减少TGFβ的表达而抑制纤维化,最终减轻瘢痕形成。本文综述了近年来TGFβ调控瘢痕形成的机制和中药通过控制TGFβ的作用而减少纤维化的研究现状。

Transforming growth factor（TGF-β）plays a central role in wound healing and scarring. TGF-β is a member of cytokine family,involving cell proliferation ,migration ,differentiation and apoptosis,wbicb subsequently trigger extraceIIular matrix（ECM）deposite and collagen overproduction. A number of regulators of TGF-β expression have been identified ,including Decorin,CTGF,etc. TCM can reduced later scarring,and it accelerates wound healing. TCM can reduce the expression of TGF-β,resistance of fibrosis,so that lighten the development of scar. This article reviewed the mechanism of TGF-β in the scarring and TCM can decrease the development of scar effected by TGF-β.