幽门螺杆菌感染的高增殖状态及其与TGF-α、EGFR表达的关系

Study on the relationship between the high proliferation of gastric epithelial cells in Hp infection and the expression of TGF α ECFR

本研究采用免疫组化ＬＳＡＢ法对幽门螺杆菌阳性和阴性胃粘膜增殖细胞核抗原（ＰＣＮＡ）、转化生长因子α（ＴＧＦ－α）、表皮生长因子受体（ＥＧＦＲ）表达进行对比分析，结果表明ＨＰ阳性胃粘膜ＰＣＮＡ、ＴＧＦ－α、ＥＧＦＲ的表达显著高于ＨＰ阴性胃粘膜（Ｐ＜０．０５），且在不典型增生时达高峰。结果提示ＨＰ感染的胃粘膜处于高增殖状态。粘膜高增殖状态可能与ＴＧＦ－α／ＥＧＦＲ过量表达有关。这也是ＨＰ致胃癌发生的机制之一。

The expression of PCNA,TGF α and EGFR in the groups of HP infection and without HP infection were observed with immunohistochemical techniques. It was shown that the expression of TGF α、EGFR and PCNA were significantly higher in HP infection group than in that without ( P <0.05). The results suggest that this increase in gastric epithelial cell proliferation was influenced by HP infection and associated with an increased risk of adenocarcinoma. The pathogenetic mechanism may be that HP infection promotes over expression of TGF α/EGFR.