摘要
Recently, the study on "induced pluripotent stem cells" (iPS cells) has made a great breakthrough, and it is considered as a new milestone in the history of life science. This progress has updated our tradi-tional concepts about pluripotency control, and provided people with a brand-new strategy for somatic cell nuclear reprogramming. In virtue of its availability and stability, this method holds great potential in both biological and clinical research. In order to introduce this rising field of study, this paper starts with an overview of the development of iPS cell establishment, describes the key steps in generating iPS cells, elaborates several relevant scientific issues, and evaluates its current restrictions and promises in future research.
Recently, the study on ＂induced pluripotent stem cells＂ （iPS cells） has made a great breakthrough, and it is considered as a new milestone in the history of life science. This progress has updated our traditional concepts about pluripotency control, and provided people with a brand-new strategy for somatic cell nuclear reprogramming. In virtue of its availability and stability, this method holds great potential in both biological and clinical research. In order to introduce this rising field of study, this paper starts with an overview of the development of iPS cell establishment, describes the key steps in generating iPS cells, elaborates several relevant scientific issues, and evaluates its current restrictions and promises in future research.
基金
Supported by the National Basic Research Program of China (Grant No. 2007CB947401)
Chinese National Manned Space Program (Grant No. 921-2)
关键词
多性干细胞
生命科学
细胞科学
细胞核修复
induced pluripotent stem cells, reprogramming, pluripotency, embryonic stem cells, differentiation
