SIOOB蛋白和神经元特异性烯醇化：能否作为心脏手术后脑损伤的生化标记

Serum SIOOB protein and neuron-specific enolase： are predictors of cerebral damage in cardiac surgery？

中枢神经功能障碍在体外循环心脏手术后的发生率很高，近年来很多研究发现血清SIOOB和NSE水平在体外循环期间明显升高，并认为二者可以作为脑损伤的生化标记物，预测心脏手术后的脑损伤；但也有的研究得出不同的结论，现就其进行综述。

Cardiac surgery correlate with a high incidence of perioperative cerebral complications. It is reported SIOOB protein and neuron -specific enolase （NSE） are predictors of cerebral damage in cardiovascular surgery. They are released after cardiac surgery performed under cardiopulmonary bypass （CPB） and their levels are correlated with the duration of CPB, deep circulatory arrest and aortic cross -clamping. Perioperative cerebral complications such as stroke, delayed awakening and confusion are associated with increased levels of S100 protein and NSE. In addition, increased levels of S100 protein are also related to neuropsychological dysfunction after cardiac surgery. But recently several researches reported that a large part of the increases in SIOOB protein and NSE during CPB was not attributed to neuronal damage, but to contamination with the blood from the surgical field. To determine whether these markers are useful to predict neurologic complications, it will be necessary to exclude all factors that might have any influence on their levels.