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癫癎猝死的研究进展 被引量：1

Research on Development of Sudden Death in Epilepsy
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摘要 癫癎患者可在没有任何结构性病理改变的情况下发生猝死,大多数癫癎猝死(SUDEP)可能与癫癎发作有关。其发生率在癫癎患者群体中为<1/1000人年,难治性癫癎组其猝死发生率达1/250人年。潜在危险因素包括癫癎发作未得到控制、治疗和监护不当等因素。其发病机制与呼吸和循环方面的异常有关,通过有效的监护可改善其呼吸状况。快速和过缓性心律失常/停搏在癫癎发作时并不少见,其基因易感性与SUDEP的潜在关系有待进一步深入研究。 Patients with epilepsy may die suddenly and unexpectedly without a structural pathological cause. Most cases of sudden unexpected death in epilepsy （SUDEP） are likely to be associated with seizures. SUDEP incidence is 〈1/1000 person-years among prevalent cases in the community and 1/250 person-years in intractable cohorts. Potential risk factors include uncontrolled convulsive seizures and factors relating to treatment and supervision. Supervision has apparently protective effect on respiratory factors. Tachyarrhythmias and bradycardia/arrest are well documented. The potential association between coexisting cardiac inherited gene determinants and SUDEP is unclear.
作者 陈旭 雷霆 李龄
机构地区 华中科技大学同济医学院附属同济医院神经外科
出处 《中国临床神经科学》 2008年第2期211-216,共6页 Chinese Journal of Clinical Neurosciences
关键词 癫痫猝死 心律失常 长QT间期综合征 危险因素 sudden unexpected death in epilepsy cardiac arrhythmia long QT syndrome risk factors
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献37

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同被引文献52

  • 1王学峰,肖争,晏勇,卢涌,马智华,李建波.癫癇患者不明原因突然死亡的临床和病理特征[J].中华神经科杂志,2004,37(6):495-499. 被引量：4
  • 2Szucs A, Lalit N, Rasonyi G, et al. Sudden death and mortality in epilepsy[J]. Ideggyogy Sz, 2006,59:321-328
  • 3Bell GS, Sander JW. Sudden unexpected death in epilepsy. Risk factors, possible mechanisms and prevention: a reappraisal[J]. Acta Neurol Taiwan, 2006,15:72-83
  • 4Christidis D, Kalogerakis D, Chan TY, et al. Is primidone the drug of choice for epileptic patients with QT-prolongation? A comprehensive analysis of literature[J]. Seizure, 2006,15:64-66
  • 5Leestma JE, Walczak T, Hughes JR, et al. A prospective study on sudden unexpected death in epilepsy[J]. Ann Neurol,1989,26:195-03
  • 6Dasheiff RM. Sudden unexpected death in epilepsy: a series from an epilepsy surgery program and speculation on the relationship to sudden cardiac death[J]. J Clin Neurophysiol,1991,8:216-222
  • 7Jick SS, Cole TB, Mesher RA, et al. Sudden unexpected death in young persons with primary epilepsy[J]. Pharmacoepidemiol Drug Saf,1992,1:59-4
  • 8Lip GY, Brodie MJ. Sudden death in epilepsy: an avoidable outcome? [J]. J R Soc Med,1992,85:609-611
  • 9Klenerman P, Sander JW, Shorvon SD. Mortality in patients with epilepsy: a study of patients in long term residential care[J]. J Neurol Neurosurg Psychiatry,1993,56:149-152
  • 10Timmings PL. Sudden unexpected death in epilepsy: a local audit [J]. Seizure, 1993,2:287-290

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中国临床神经科学
2008年 第2期

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