摘要
过氧化物体增殖物激活受体(PPARs)是核激素受体超家族的新成员,是一类由配体激活的转录因子,在体内组织广泛表达并具有多种生物学效应。其中PPARγ激动剂噻唑烷二酮类(TZDs)除了降低血糖、改善胰岛素抵抗外,还具有胰岛素增敏之外的作用如降低蛋白尿、改善血流动力学、抑制系膜增生、抑制间质纤维化、保护足细胞等。仅就TZDs对糖尿病肾病的直接肾保护作用及机制进行综述。
Peroxiseme proliferator-activated receptors（PPAR） are new members of the nuclear hormone receptor superfamily,which is a kind of ligand-activated transcription factors, and extensively expressed in many tissues of the body having various biological effects. PPARγ agonists thiazolidinediones（TZDs） not only has the effects of lowering blood sugar and promoting insulin resisitance,but also has another effects except for inulin sensitization, such as lowering the proteinuria, promoting hemodynamies, inhibiting mesangial proliferation, inhibiting interstitial fibrosis and protecting podecyte. This article reviews the direct protective effects on diabetic nephropathy and possible mechanisms of thiazolidinediones.
出处
《医学综述》
2008年第5期733-735,共3页
Medical Recapitulate
