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PPARs与皮肤病的关系研究进展 被引量：1

Advances of relationship between PPARs and dermatosis (Review)
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摘要 过氧化物酶体增殖物激活受体(PPARs)在过氧化物酶体增殖、脂肪生成、β氧化增加和细胞周期的调节等方面起着重要作用,它在皮肤生理及病理方面的作用逐渐受到重视。PPARα影响皮肤的成熟、分化和增殖,皮肤外伤后,PPARβ/δ一直保持表达直到创口愈合。PPARs对皮脂形成、皮肤肿瘤发展有不同的影响,在银屑病和色素性皮肤病中也起一定的作用。这些发现可为治疗皮肤病提供新途径。 This article detailed PPARs have relative with （ 1 ） maturation, differentiation, mutiplication of skin, （2） heal of wound, （3） acne ＇ （4） tumor of skin, （ 5 ） psoriasis, （ 6 ） pigmantal skin disease.
作者 王燕 周晓鸿 李晓岚
机构地区 云南省大理学院临床学院皮肤护理教研室 昆明医学院第二附属医院皮肤科
出处 《皮肤病与性病》 2008年第1期22-24,共3页 Dermatology and Venereology
关键词 PPARS 皮肤病 综述 PPARs Dermatosis Review.
分类号 Q274 [生物学—细胞生物学] R758.4 [医药卫生—皮肤病学与性病学]
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参考文献30

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同被引文献26

  • 1Baregamian Net al. PPARy agonist protects against intestinal injury during necrotizing enterocolitis. Biochem Biophys Res Commun, 2009, 379(2): 423-427.
  • 2Landreth G et al. PPAR7 agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics, 2008, 5 (3): 481-489.
  • 3Drew PD et al. PPAR-y: therapeutic potential for multiple sclerosis. PPAR Res, 2008, doi: 10.1155/2008/627463.
  • 4Remels AH et al. PPARy inhibits NF-K:B-dependent transcriptional activation in skeletal muscle. Am J Physiol Endocrinol Metab, 2009, 297(1): E174-E183.
  • 5Sundararajan Set al. Peroxisome proliferator-activated receptor-y ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscienee, 2005, 130(3): 685- 696.
  • 6Victor NA et al. Altered PPART expression and activation after transient focal ischemia in rats. Eur J Neurosci, 2006, 24(6): 1653-1663.
  • 7Zhao X et al. Neuronal PPARy deficiency increases susceptibility to brain damage after cerebral ischemia. J Neurosci, 2009, 29 (19): 6186-6195.
  • 8Duan SZ et al. PPARs: the vasculature, inflammation and hypertension. Curr Opin Nephrol Hypertens, 2009, 18(2): 128-133.
  • 9Tesse A et al. PPARδ activity in cardiovascular diseases: a potential pharmacological target. PPAR Res, 2009, doi: 10. 1155/2009/745821.
  • 10Michalik Let al. PPARs mediate lipid signaling in inflammation and cancer. PPAR Res, 2008, doi: 10.1155/2008/134059.

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皮肤病与性病
2008年 第1期

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